Publication Date

2011

Journal

The Texas Heart Journal

PMID

21494520

Publication Date(s)

2011

Language

English

PMCID

PMC3066827

PubMedCentral® Posted Date

2011

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

Age Factors, Aged, Aging, Clinical Trials as Topic, Estrogen Replacement Therapy, Evidence-Based Medicine, Female, Heart Diseases, Humans, Middle Aged, Patient Selection, Postmenopause, Primary Prevention, Risk Assessment, Risk Factors, Secondary Prevention, Sex Factors, Treatment Outcome, Women's Health

Abstract

Results from more than 40 observational studies conducted in women over 3 decades have repeatedly indicated the cardioprotective effects of postmenopausal hormone replacement therapy (HRT). Women taking estrogen in these observational trials experienced a consistent 30% to 50% reduction in cardiovascular (CV) events. The biologic benefit of estrogen has been attributed to improvements in lipid profiles and endothelial function.

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