Publication Date
2011
Journal
The Texas Heart Journal
PMID
21494520
Publication Date(s)
2011
Language
English
PMCID
PMC3066827
PubMedCentral® Posted Date
2011
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Age Factors, Aged, Aging, Clinical Trials as Topic, Estrogen Replacement Therapy, Evidence-Based Medicine, Female, Heart Diseases, Humans, Middle Aged, Patient Selection, Postmenopause, Primary Prevention, Risk Assessment, Risk Factors, Secondary Prevention, Sex Factors, Treatment Outcome, Women's Health
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Results from more than 40 observational studies conducted in women over 3 decades have repeatedly indicated the cardioprotective effects of postmenopausal hormone replacement therapy (HRT). Women taking estrogen in these observational trials experienced a consistent 30% to 50% reduction in cardiovascular (CV) events. The biologic benefit of estrogen has been attributed to improvements in lipid profiles and endothelial function.