Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation.

Authors

Brittney Ferguson
Nishantha R Bokka
Krishna Rao Maddipati
Srinivas Ayilavarapu
Robin Weltman
Lisha Zhu
Wanqi Chen
W Jim Zheng
Nikola Angelov
Thomas E Van Dyke
Chun-Teh Lee

Publication Date

1-1-2020

Journal

Frontiers in Immunology

Abstract

Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in gingiva of subjects with periodontitis to healthy controls. A total of 28 subjects were included; 13 periodontally healthy and 15 periodontitis before or after non-surgical periodontal therapy. Gingival tissues were collected from two representative posterior teeth prior to and 8 weeks after scaling and root planning; only once in the healthy group. Lipid mediator-SPM metabololipidomics was performed to identify metabolites in gingiva. qRT-PCR was performed to assess relative gene expression (2

Keywords

Adult, Fatty Acids, Female, Gene Expression, Gingiva, Humans, Male, Metabolomics, Middle Aged, Periodontitis, Receptors, G-Protein-Coupled, Young Adult

Recommended Citation

Ferguson, Brittney; Bokka, Nishantha R; Maddipati, Krishna Rao; Ayilavarapu, Srinivas; Weltman, Robin; Zhu, Lisha; Chen, Wanqi; Zheng, W Jim; Angelov, Nikola; Van Dyke, Thomas E; and Lee, Chun-Teh, "Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation." (2020). Journal Articles. 36.
https://digitalcommons.library.tmc.edu/uthdb_docs/36