Distinct Profiles of Specialized Pro-Resolving Lipid Mediators and Corresponding Receptor Gene Expression In Periodontal Inflammation

Authors

Language

English

Publication Date

1-1-2020

Journal

Frontiers in Immunology

DOI

10.3389/fimmu.2020.01307

PMID

32670289

PMCID

PMC7330171

PubMedCentral® Posted Date

June 2020

PubMedCentral® Full Text Version

Post-print

Abstract

Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in gingiva of subjects with periodontitis to healthy controls. A total of 28 subjects were included; 13 periodontally healthy and 15 periodontitis before or after non-surgical periodontal therapy. Gingival tissues were collected from two representative posterior teeth prior to and 8 weeks after scaling and root planning; only once in the healthy group. Lipid mediator-SPM metabololipidomics was performed to identify metabolites in gingiva. qRT-PCR was performed to assess relative gene expression (2

Keywords

Adult, Fatty Acids, Female, Gene Expression, Gingiva, Humans, Male, Metabolomics, Middle Aged, Periodontitis, Receptors, G-Protein-Coupled, Young Adult

Recommended Citation

, "Distinct Profiles of Specialized Pro-Resolving Lipid Mediators and Corresponding Receptor Gene Expression In Periodontal Inflammation" (2020). Faculty, Staff and Student Publications. 36.
https://digitalcommons.library.tmc.edu/uthdb_docs/36