Trem-1, Trem-2 and Their Association With Disease Severity in Patients With COVID-19

Authors

Ruyue Fan
Zuowang Cheng
Zhisheng Huang
Ying Yang
Na Sun
Bin Hu
Peibin Hou
Bo Liu
Chuanjun Huang
Shuai Liu

Publication Date

1-1-2023

Journal

Annals of Medicine

Abstract

BACKGROUND: Delayed diagnosis and inadequate treatment caused by limited biomarkers are associated with the outcomes of COVID-19 patients. It is necessary to identify other promising biomarkers and candidate targets for defining dysregulated inflammatory states.

METHODS: The triggering receptors expressed on myeloid cell (TREM)-1 and TREM-2 expression from hospitalized COVID-19 patients were characterized using ELISA and flow cytometry, respectively. Their correlation with disease severity and contrast with the main clinical indicators were evaluated.

RESULTS: Increased expression of soluble TREM-1 and TREM-2 in the plasma of COVID-19 patients was found compared to the control group. Moreover, membrane-bound TREM-1 and TREM-2 expression was upregulated on the cell surface of circulating blood T cells from COVID-19 patients. Correlation analysis showed that sTREM-2 levels were negatively correlated with PaO

CONCLUSION: TREM-2 and TREM-1 are critical host immune factors that response to SARS-COV-2 infection and could serve as potential diagnostic biomarkers and therapeutic targets for COVID-19.

Keywords

Humans, Triggering Receptor Expressed on Myeloid Cells-1, Membrane Glycoproteins, Receptors, Immunologic, COVID-19, SARS-CoV-2, Biomarkers, C-Reactive Protein, Myeloid Cells, Procalcitonin, Interleukin-6, Patient Acuity, TREM-1, TREM-2, disease severity, COVID-19

Comments

Supplementary Materials

PMID: 37848000