The Fibro-Adipogenic Progenitor APOD+DCN+lLUM+ Cell Population in Aggressive Carcinomas

Authors

Lingyi Cai
Mikhail G Kolonin
Dimitris Anastassiou

Publication Date

9-1-2024

Journal

Cancer Metastasis Review

Abstract

We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined multigene signature including APOD, DCN, and LUM. This cell population has previously been labeled as consisting of inflammatory cancer-associated fibroblasts (iCAFs). The same signature characterizes naturally occurring fibro-adipogenic progenitors (FAPs) as well as stromal cells abundant in normal adipose tissue. Our analysis of human gene expression databases provides evidence that adipose stromal cells (ASCs) are recruited by tumors and undergo differentiation into CAFs during cancer progression to invasive and chemotherapy-resistant stages.

Keywords

Humans, Animals, Adipogenesis, Carcinoma, Stem Cells, Cancer-Associated Fibroblasts, Adipose Tissue, Neoplasms

Comments

Supplementary Materials

PMID: 38466528