Student and Faculty Publications
Publication Date
3-19-2024
Journal
Cellular and Molecular Life Sciences
Abstract
Complications associated with Type 1 and Type 2 diabetes, such as diabetic peripheral neuropathy and diabetic foot ulcers, are a growing health-care concern. In addition, this concern increases as diabetic patients age due to their increased susceptibility to complications. To address this growing problem, it is important to understand fluctuations in physiology which lead to pathological changes associated with the metabolic disturbances of diabetes. Our study explores dysregulation of immune cell populations in the hindpaws of healthy and diabetic mice at 12 and 21 weeks of age using single-cell RNA sequencing to provide insight into immune disruptions occurring in the distal limb during chronic diabetes. In 21-week-old Lepr
Keywords
Humans, Mice, Animals, Diabetes Mellitus, Type 2, Diabetes Mellitus, Experimental, Immunity, Innate, Lymphocytes, Leukocytes, Single-Cell Analysis
Included in
Animals Commons, Bioinformatics Commons, Biomedical Informatics Commons, Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Internal Medicine Commons, Medical Sciences Commons
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Associated Data
PMID: 38502310