Faculty, Staff and Student Publications

Language

English

Publication Date

6-1-2026

Journal

Trends in Endocrinology & Metabolism

DOI

10.1016/j.tem.2025.09.008

PMID

41109800

PMCID

PMC12677156

PubMedCentral® Posted Date

10-18-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

The liver possesses a unique regenerative capacity, driven by mechanisms that extend beyond classical growth factor signaling. Recent studies underscore the importance of metabolic reprogramming, mitochondrial adaptation, and signaling metabolites in promoting tissue injury repair. Dynamic crosstalk between hepatocytes, non-parenchymal cells, and other organs governs the regenerative process. Spatial compartmentalization within the liver and systemic cues from adipose tissue, the pancreas, the gut, the brain, skeletal muscle, and other organs play critical roles in shaping regenerative outcomes. In this review we discuss how the liver's tissue microenvironment and inter-organ communication networks regulate liver regeneration, providing new insights into the complex biology underlying tissue repair.

Keywords

Liver Regeneration, Humans, Animals, Liver, Signal Transduction, Hepatocytes, Metabolic Reprogramming, Liver regeneration, metabolism, immune cells, intrahepatic microenvironment, inter-organ communication

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.