Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Authors

João M Anghinoni
Paloma T Birmann
Marcia J da Rocha
Caroline S Gomes
Michael J Davies
César A Brüning
Lucielli Savegnago
Eder J Lenardão

Publication Date

10-30-2023

Journal

Molecules

Abstract

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

Keywords

antioxidant, organoselenium, GPx-like, DPPH, ABTS, FRAP, catalase, SOD, lipid peroxidation