Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis

Authors

Piu Saha
Blair Mell
Rachel M Golonka
Venugopal R Bovilla
Ahmed A Abokor
Xue Mei
Beng San Yeoh
Peter A Doris
Andrew T Gewirtz
Bina Joe
Matam Vijay-Kumar

Publication Date

10-1-2022

Journal

Hypertension

Abstract

BACKGROUND: The spontaneously hypertensive rat (SHR) is extensively used to study hypertension. Gut microbiota dysbiosis is a notable feature in SHR for reasons unknown. Immunoglobulin A (IgA) is a major host factor required for gut microbiota homeostasis. We hypothesized that inadequate IgA contributes to gut microbiota dysbiosis in SHR.

METHODS: IgA was measured in feces, cecum, serum, liver, gut-associated lymphoid tissue, and milk from SHR and Wistar Kyoto rats. IgA regulatory factors like IgM, IgG, and

RESULTS: Compared with Wistar Kyoto rats, SHR displayed remarkably near-deficient IgA levels accompanied by compensatory increases in serum IgM and IgG and gut-liver

CONCLUSIONS: This study is the first to reveal IgA deficiency in SHR as one host factor associated with gut microbiota dysbiosis and invigorates future research to determine the pathophysiological role of IgA in hypertension.

Keywords

Animals, Blood Pressure, Dysbiosis, Hypertension, IgA Deficiency, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Rats, Rats, Inbred SHR, Rats, Inbred WKY

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Supplementary Materials

PMID: 35950503