Cardiovascular Risk Factors in Sheehan's Syndrome: A Case-Control Study

Authors

Mayur Agrawal
Subhash C Yadav
Swish K Singh
Sheo Kumar
Krishnarpan Chatterjee
Naveen K Garg

Publication Date

1-1-2024

Journal

Indian Journal of Endocrinology and Metabolism

Abstract

INTRODUCTION: Obesity, dyslipidaemia and insulin resistance are associated with hypopituitarism. The association between these conditions and Sheehan's syndrome (SS) caused by post-partum pituitary gland necrosis is poorly understood. This study aimed to assess cardiovascular risk surrogate markers in SS patients, and we compared clinical, biochemical and radiological testing with healthy controls.

METHODS: In this cross-sectional study, we studied 45 patients with SS on standard replacement therapy and compared them with healthy controls. All subjects underwent anthropometric, inflammatory marker and hormonal measurement (adrenocorticotropic hormone (ACTH), stimulated cortisol, insulin-like growth factor-1 (IGF-1), thyroxine (T4), follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol (E2), prolactin (Prl), insulin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP)). Carotid intima-media thickness (CIMT), flow-mediated dilation (FMD) and echocardiography were also performed.

RESULTS: The mean age and body mass index (BMI) of SS patients were 48.1 ± 10.0 years and 24.3 ± 4.3 kg/m

CONCLUSION: SS patients show increased cardiovascular risk with hypertension, dyslipidaemia and increased atherosclerotic and inflammatory markers.

Keywords

Cardiovascular risk, dyslipidaemia, hypopituitarism, insulin resistance, metabolic syndrome, sheehan syndrome

Comments

PMID: 39086563