PANoptosis Is a Prominent Feature of Desmoplakin Cardiomyopathy

Authors

Melis Olcum
Leila Rouhi
Siyang Fan
Maya M Gonzales
Hyun-Hwan Jeong
Zhongming Zhao
Priyatansh Gurha
Ali J Marian

Publication Date

2-1-2023

Journal

The Journal of Cardiovascular Aging

Abstract

INTRODUCTION: Arrhythmogenic cardiomyopathy (ACM) is hereditary cardiomyopathy caused by pathogenic variants (mutations) in genes encoding the intercalated disc (ID), particularly desmosome proteins. ACM caused by mutations in the

AIM: The aim of this article was to gain insight into the pathogenesis of DSP cardiomyopathy.

METHODS AND RESULTS: The

CONCLUSION: The findings identify PANoptosis as a prominent phenotypic feature of DSP cardiomyopathy and set the stage for delineating the specific molecular mechanisms involved in its pathogenesis. The model also provides the opportunity to test the effects of pharmacological and genetic interventions on myocardial fibrosis and cell death.

Keywords

Desmoplakin cardiomyopathy, PANoptosis, apoptosis, necroptosis, pyroptosis, inflammation, fibrosis

Comments

Supplementary Materials

PMID: 36818425