FusionPDB:: A Knowledgebase of Human Fusion Proteins

Authors

Language

English

Publication Date

1-5-2024

Journal

Nucleic Acids Research

DOI

10.1093/nar/gkad920

PMID

37870473

PMCID

PMC10767906

PubMedCentral® Posted Date

January 2024

PubMedCentral® Full Text Version

Post-print

Abstract

Tumorigenic functions due to the formation of fusion genes have been targeted for cancer therapeutics (i.e. kinase inhibitors). However, many fusion proteins involved in various cellular processes have not been studied for targeted therapeutics. This is because the lack of complete fusion protein sequences and their whole 3D structures has made it challenging to develop new therapeutic strategies. To fill these critical gaps, we developed a computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth.edu/FusionPDB. FusionPDB is organized into four levels: 43K fusion protein sequences (14.7K in-frame fusion genes, Level 1), over 2300 + 1267 fusion protein 3D structures (from 2300 recurrent and 266 manually curated in-frame fusion genes, Level 2), pLDDT score analysis for the 1267 fusion proteins from 266 manually curated fusion genes (Level 3), and virtual screening outcomes for 68 selected fusion proteins from 266 manually curated fusion genes (Level 4). FusionPDB is the only resource providing whole 3D structures of fusion proteins and comprehensive knowledge of human fusion proteins. It will be regularly updated until it covers all human fusion proteins in the future.

Keywords

Humans, Amino Acid Sequence, Knowledge Bases, Neoplasms, Databases, Protein, Protein Conformation

Published Open-Access

yes

Recommended Citation

, "FusionPDB:: A Knowledgebase of Human Fusion Proteins" (2024). Faculty, Staff and Student Publications. 236.
https://digitalcommons.library.tmc.edu/uthshis_docs/236