Opportunities and Challenges in Developing a Cryptosporidium Controlled Human infection Model For Testing antiparasitic agents

Authors

Rajiv S Jumani
Johanne Blais
Hanns-Christian Tillmann
Florencia Segal
Dean Wetty
Christian Ostermeier
Natko Nuber
Jay Lakshman
Natasha Aziz
Richa Chandra
Wilbur H Chen
Cynthia L Chappell
Thierry T Diagana
Ujjini H Manjunatha

Publication Date

5-14-2021

Journal

ACS Infectious Diseases

Abstract

Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality in children younger than two years of age, and it is also strongly associated with childhood malnutrition and growth stunting. There is no vaccine for cryptosporidiosis and existing therapeutic options are suboptimal to prevent morbidity and mortality in young children. Recently, novel therapeutic agents have been discovered through high-throughput phenotypic and target-based screening strategies, repurposing malaria hits, etc., and these agents have a promising preclinical in vitro and in vivo anti-

Keywords

Adult, Antiparasitic Agents, Child, Child, Preschool, Cryptosporidiosis, Cryptosporidium, Diarrhea, Humans, Malaria