Faculty, Staff and Student Publications
Publication Date
1-28-2021
Journal
Nature Communications
Abstract
Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working Group on Sarcopenia in Older People definition: n = 48,596 cases, 18.9% of total), including 12 loci not implicated in previous analyses of continuous measures of grip strength. Loci include genes reportedly involved in autoimmune disease (HLA-DQA1 p = 4 × 10
Keywords
Aged, Aged, 80 and over, Aging, Cohort Studies, Europe, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Growth Differentiation Factor 5, HLA-DQ alpha-Chains, Humans, Male, Middle Aged, Muscle Strength, Muscle Weakness, Polymorphism, Single Nucleotide, Sarcopenia