Cas9/Nickase-induced allelic Conversion By Homologous Chromosome-Templated Repair in

Authors

Sitara Roy
Sara Sanz Juste
Marketta Sneider
Ankush Auradkar
Carissa Klanseck
Zhiqian Li
Alison Henrique Ferreira Julio
Victor Lopez del Amo
Ethan Bier
Annabel Guichard

Publication Date

7-1-2022

Journal

Science Advances

Abstract

Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template. Here, a

Keywords

Alleles, Animals, CRISPR-Cas Systems, Chromatids, Deoxyribonuclease I, Drosophila