Cas9/Nickase-induced allelic Conversion By Homologous Chromosome-Templated Repair in Drosophila somatic cells

Authors

Sitara Roy
Sara Sanz Juste
Marketta Sneider
Ankush Auradkar
Carissa Klanseck
Zhiqian Li
Alison Henrique Ferreira Julio
Victor Lopez del Amo
Ethan Bier
Annabel Guichard

Language

English

Publication Date

7-1-2022

Journal

Science Advances

DOI

10.1126/sciadv.abo0721

PMID

35776792

PMCID

PMC10883370

PubMedCentral® Posted Date

July 2022

PubMedCentral® Full Text Version

Post-print

Abstract

Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template. Here, a

Keywords

Alleles, Animals, CRISPR-Cas Systems, Chromatids, Deoxyribonuclease I, Drosophila

Recommended Citation

Roy, Sitara; Juste, Sara Sanz; Sneider, Marketta; et al., "Cas9/Nickase-induced allelic Conversion By Homologous Chromosome-Templated Repair in Drosophila somatic cells" (2022). Faculty, Staff and Student Publications. 415.
https://digitalcommons.library.tmc.edu/uthsph_docs/415