Biomimetic Copper-Doped Polypyrrole Nanoparticles For Enhanced Cancer Low-Temperature Photothermal therapy

Authors

Hao Chen
Xi Luo
Wei Cai
Shile Wang
Jingfeng Xiang
Zeming Liu
Daoming Zhu

Publication Date

1-1-2023

Journal

International Journal of Nanomedicine

Abstract

INTRODUCTION: Photothermal therapy (PTT) has a significant potential for its application in precision tumour therapy. However, PTT-induced hyperthermia may damage healthy tissues and trigger the expression of heat shock proteins (HSPs), thereby compromising the long-term therapeutic efficacy of PTT.

METHODS: In this study, a biomimetic drug delivery system comprising CuP nanozymes as the inner core and platelet membrane (PM) as the outer shell was successfully developed for administering synergistic chemodynamic therapy and mild PTT. PM is encapsulated on CuP to form this biomimetic nanoparticle (PM-coated CuP nanoparticles, PC). PC possesses peroxidase (POD) activity, can facilitate the conversion of hydrogen peroxide into ·OH, thereby inhibiting the expression of HSPs.

RESULTS: Upon exposure to low-power laser irradiation (0.5 W/cm

DISCUSSION: PC exhibits high efficacy and biocompatibility, making it a promising candidate for future applications.

Keywords

Humans, Polymers, Pyrroles, Phototherapy, Copper, Photothermal Therapy, Biomimetics, Temperature, Nanoparticles, Neoplasms, Cell Line, Tumor