Faculty, Staff and Student Publications
Publication Date
1-1-2023
Journal
International Journal of Nanomedicine
Abstract
INTRODUCTION: Photothermal therapy (PTT) has a significant potential for its application in precision tumour therapy. However, PTT-induced hyperthermia may damage healthy tissues and trigger the expression of heat shock proteins (HSPs), thereby compromising the long-term therapeutic efficacy of PTT.
METHODS: In this study, a biomimetic drug delivery system comprising CuP nanozymes as the inner core and platelet membrane (PM) as the outer shell was successfully developed for administering synergistic chemodynamic therapy and mild PTT. PM is encapsulated on CuP to form this biomimetic nanoparticle (PM-coated CuP nanoparticles, PC). PC possesses peroxidase (POD) activity, can facilitate the conversion of hydrogen peroxide into ·OH, thereby inhibiting the expression of HSPs.
RESULTS: Upon exposure to low-power laser irradiation (0.5 W/cm
DISCUSSION: PC exhibits high efficacy and biocompatibility, making it a promising candidate for future applications.
Keywords
Humans, Polymers, Pyrroles, Phototherapy, Copper, Photothermal Therapy, Biomimetics, Temperature, Nanoparticles, Neoplasms, Cell Line, Tumor