Publication Date
9-30-2023
Journal
Molecules and Cells
DOI
10.14348/molcells.2023.0074
PMID
37305954
PMCID
PMC10495687
PubMedCentral® Posted Date
6-12-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
no
Keywords
Rats, Animals, Sphingomyelins, Sphingomyelin Phosphodiesterase, Cytochromes c, Ceramides, Mitochondria, Brain
Abstract
Sphingomyelinase (SMase) catalyzes ceramide production from sphingomyelin. Ceramides are critical in cellular responses such as apoptosis. They enhance mitochondrial outer membrane permeabilization (MOMP) through self-assembly in the mitochondrial outer membrane to form channels that release cytochrome c from intermembrane space (IMS) into the cytosol, triggering caspase-9 activation. However, the SMase involved in MOMP is yet to be identified. Here, we identified a mitochondrial Mg
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