Language
English
Publication Date
9-30-2023
Journal
Molecules and Cells
DOI
10.14348/molcells.2023.0074
PMID
37305954
PMCID
PMC10495687
PubMedCentral® Posted Date
6-12-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Sphingomyelinase (SMase) catalyzes ceramide production from sphingomyelin. Ceramides are critical in cellular responses such as apoptosis. They enhance mitochondrial outer membrane permeabilization (MOMP) through self-assembly in the mitochondrial outer membrane to form channels that release cytochrome c from intermembrane space (IMS) into the cytosol, triggering caspase-9 activation. However, the SMase involved in MOMP is yet to be identified. Here, we identified a mitochondrial Mg
Keywords
Rats, Animals, Sphingomyelins, Sphingomyelin Phosphodiesterase, Cytochromes c, Ceramides, Mitochondria, Brain
Published Open-Access
yes
Recommended Citation
Choi, Jong Min; Piao, Yongwei; Ahn, Kyong Hoon; et al., "Purification and Characterization of Mitochondrial Mg2+-Independent Sphingomyelinase from Rat Brain" (2023). Faculty and Staff Publications. 100.
https://digitalcommons.library.tmc.edu/baylor_docs/100