Publication Date
4-1-2020
Journal
Scientific Reports
DOI
10.1038/s41598-020-62768-4
PMID
32238835
PMCID
PMC7113244
PubMedCentral® Posted Date
4-1-2020
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Anticoagulants, Blood Coagulation, Blood Coagulation Tests, Blood Platelets, Child, Child, Preschool, Drug Monitoring, Equipment Design, Extracorporeal Membrane Oxygenation, Fibrin, Fibrinolytic Agents, Humans, Lab-On-A-Chip Devices, Thrombosis, Thrombosis, Biomedical engineering
Abstract
Accurate assessment of blood thrombosis and antithrombotic therapy is essential for the management of patients in a variety of clinical conditions, including surgery and on extracorporeal life support. However, current monitoring devices do not measure the effects of hemodynamic forces that contribute significantly to coagulation, platelet function and fibrin formation. This limits the extent to which current assays can predict clotting status in patients. Here, we demonstrate that a biomimetic microfluidic device consisting stenosed and tortuous arteriolar vessels would analyze blood clotting under flow, while requiring a small blood volume. When the device is connected to an inline pressure sensor a clotting time analysis is applied, allowing for the accurate measurement of coagulation, platelets and fibrin content. Furthermore, this device detects a prolonged clotting time in clinical blood samples drawn from pediatric patients on extracorporeal membrane oxygenation receiving anticoagulant therapy. Thus, this tortuosity activated microfluidic device could lead to a more quantitative and rapid assessment of clotting disorders and their treatment.
Included in
Biomedical Informatics Commons, Cardiology Commons, Cardiovascular Diseases Commons, Medical Sciences Commons
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