Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

Authors

Neda Rasouli
Naji Younes
Kristina M Utzschneider
Silvio E Inzucchi
Ashok Balasubramanyam
Andrea L Cherrington
Faramarz Ismail-Beigi
Robert M Cohen
Darin E Olson
Ralph A DeFronzo
William H Herman
John M Lachin
Steven E Kahn
GRADE Research Group

Publication Date

2-1-2021

Journal

Diabetes Care

DOI

10.2337/dc20-1787

PMID

33334808

PMCID

PMC7818323

PubMedCentral® Posted Date

12-17-2020

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Blood Glucose, C-Peptide, Child, Child, Preschool, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Infant, Insulin, Insulin Resistance, Male

Abstract

OBJECTIVE: We investigated sex and racial differences in insulin sensitivity, β-cell function, and glycated hemoglobin (HbA

RESEARCH DESIGN AND METHODS: This is a cross-sectional analysis of baseline data from 3,108 GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) participants. All had type 2 diabetes diagnosedβ-cell function were evaluated using the HOMA of insulin sensitivity and estimates from oral glucose tolerance tests, including the Matsuda Index, insulinogenic index, C-peptide index, and oral disposition index (DI).

RESULTS: The cohort was 56.6 ± 10 years of age (mean ± SD), 63.8% male, with BMI 34.2 ± 6.7 kg/m

CONCLUSIONS: In the GRADE cohort, β-cell function differed by sex and race and was associated with the concurrent level of HbA