In Silico Integrative Analysis of Multi-Omics Reveals Regulatory Layers for Diurnal Gene Expression in Mouse Liver

Authors

Chunjie Jiang
Panpan Liu
Cam Mong La
Dongyin Guan

Publication Date

1-1-2022

Journal

Frontiers in Endocrinology

DOI

10.3389/fendo.2022.955070

PMID

35937828

PMCID

PMC9353712

PubMedCentral® Posted Date

7-22-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Animals, Circadian Rhythm, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Gene Expression, Liver, Mice, RNA

Abstract

Diurnal oscillation persists throughout the body and plays an essential role in maintaining physiological homeostasis. Disruption of diurnal rhythm contributes to many diseases including type 2 diabetes. The regulatory mechanism of the transcription-translation feedback loop (TTFL) of core clock genes is well-established, while a systematic study across all regulatory layers of gene expression, including gene transcription, RNA translation, and DNA binding protein (DBP) activities, is still lacking. We comprehensively bioinformatics analyzed the rhythmicity of gene transcription, mature RNA abundance, protein abundance and DBP activity using publicly available omic-datasets from mouse livers. We found that the core clock genes,

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