Language
English
Publication Date
11-1-2022
Journal
Experimental and Clinical Endocrinology & Diabetes
DOI
10.1055/a-1913-7900
PMID
36075228
PMCID
PMC9678439
PubMedCentral® Posted Date
11-1-2022
PubMedCentral® Full Text Version
Post-print
Abstract
PURPOSE: To investigate the clinical characteristics and associated factors of colonic polyps in patients with acromegaly.
METHODS: Clinical characteristics and colonoscopy findings of 86 acromegaly patients who received treatment were retrospectively reviewed, and colonoscopy findings and the correlation with growth hormone (GH)-secreting pituitary adenoma (GHPA) volume and hormonal/metabolic levels were analyzed.
RESULTS: The prevalence of colonic polyps in acromegaly patients was 40.7% and increased significantly with advanced age, especially in those ≥50 years. Multiple polyps (62.8%) and colonic polyps in the left colon (54.2%) were detected more frequently. Compared to acromegaly patients without polyps, those with polyps displayed higher insulin-like growth factor-1 × upper limit of normal (IGF-1×ULN) levels (P=0.03). IGF-1 levels and GHPA volumes in patients with polyps showed increasing trends, although the differences were not significant. GH levels were higher in patients with polyps of diameter ≤5 mm than those with polyps of diameter >5 mm (P=0.031). The univariate and multivariate logistic regression analysis revealed that GHPA volumes (OR: 1.09, 95% CI: 1.01-1.20; P=0.039) and IGF-1×ULN Q2 levels (OR: 6.51, 95% CI: 1.20-44.60; P=0.038) were independent factors for predicting the risk of colonic polyp occurrence in acromegaly patients. A nomogram was prepared to evaluate the risk of colonic polyps in acromegaly patients.
CONCLUSION: The acromegalic patients are a population with a high prevalence of colonic polyps. GHPA volumes and IGF-1×ULN levels may be predictors of colonic polyp occurrence.
Keywords
Humans, Middle Aged, Colonic Polyps, Acromegaly, Insulin-Like Growth Factor I, Retrospective Studies, Growth Hormone-Secreting Pituitary Adenoma, Adenoma, acromegaly, colonic polyps, growth hormone (GH), colonoscopy, insulin-like growth factor-1(IGF-1)
Published Open-Access
yes
Recommended Citation
Peng, Guiliang; Li, Xing; Zhou, Yuanyuan; et al., "Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly" (2022). Faculty and Staff Publications. 1125.
https://digitalcommons.library.tmc.edu/baylor_docs/1125
Included in
Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Medical Sciences Commons