Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly

Authors

Guiliang Peng
Xing Li
Yuanyuan Zhou
Jianying Bai
Pian Hong
Weixing Li
Yuling Zhang
Lei Zhang
Qian Liao
Mingyu Liao
Ling Zhou
Zheng Sun
Rufei Shen
Hongting Zheng
Min Long

Publication Date

11-1-2022

Journal

Experimental and Clinical Endocrinology & Diabetes

DOI

10.1055/a-1913-7900

PMID

36075228

PMCID

PMC9678439

PubMedCentral® Posted Date

11-1-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Middle Aged, Colonic Polyps, Acromegaly, Insulin-Like Growth Factor I, Retrospective Studies, Growth Hormone-Secreting Pituitary Adenoma, Adenoma, acromegaly, colonic polyps, growth hormone (GH), colonoscopy, insulin-like growth factor-1(IGF-1)

Abstract

PURPOSE: To investigate the clinical characteristics and associated factors of colonic polyps in patients with acromegaly.

METHODS: Clinical characteristics and colonoscopy findings of 86 acromegaly patients who received treatment were retrospectively reviewed, and colonoscopy findings and the correlation with growth hormone (GH)-secreting pituitary adenoma (GHPA) volume and hormonal/metabolic levels were analyzed.

RESULTS: The prevalence of colonic polyps in acromegaly patients was 40.7% and increased significantly with advanced age, especially in those ≥50 years. Multiple polyps (62.8%) and colonic polyps in the left colon (54.2%) were detected more frequently. Compared to acromegaly patients without polyps, those with polyps displayed higher insulin-like growth factor-1 × upper limit of normal (IGF-1×ULN) levels (P=0.03). IGF-1 levels and GHPA volumes in patients with polyps showed increasing trends, although the differences were not significant. GH levels were higher in patients with polyps of diameter ≤5 mm than those with polyps of diameter >5 mm (P=0.031). The univariate and multivariate logistic regression analysis revealed that GHPA volumes (OR: 1.09, 95% CI: 1.01-1.20; P=0.039) and IGF-1×ULN Q2 levels (OR: 6.51, 95% CI: 1.20-44.60; P=0.038) were independent factors for predicting the risk of colonic polyp occurrence in acromegaly patients. A nomogram was prepared to evaluate the risk of colonic polyps in acromegaly patients.

CONCLUSION: The acromegalic patients are a population with a high prevalence of colonic polyps. GHPA volumes and IGF-1×ULN levels may be predictors of colonic polyp occurrence.

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