Publication Date
7-1-2024
Journal
Journal of Geriatric Psychiatry and Neurology
DOI
10.1177/08919887231215041
PMID
37950647
PMCID
PMC11087374
PubMedCentral® Posted Date
11-11-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Aged, Aged, 80 and over, Female, Humans, Male, Body Mass Index, C-Reactive Protein, Cross-Sectional Studies, Depression, Obesity, Sex Factors, Biomarkers, depression, geriatric psychiatry, geriatrics, elderly, mental health, neurochemistry
Abstract
OBJECTIVES: To test the hypothesis that depressive symptoms vary with high-sensitivity C-reactive protein (hs-CRP), among older adults with obesity.
METHODS: This was a cross-sectional, secondary analysis of baseline data from two related lifestyle intervention trials. The study sample comprises 148 consecutively recruited, community-dwelling older adults (age >=65 years) without severe psychiatric illness and with body mass index >=30 kg/m
RESULTS: Sample mean GDS score was 2.7 (SD 3.0, range 0 - 14). A significant multivariate model of GDS scores (R
CONCLUSIONS: In older adults with obese BMI, male sex and higher hs-CRP are associated with depression, even in a group with relatively minimal depressive symptoms. Hs-CRP may offer clinical utility as a biomarker for depression among older adults with obese BMI, even among those with non-severe psychiatric symptomatology.
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