Indices of Sarcopenic Obesity Are Important Predictors of Finite Element Analysis-Derived Bone Strength in Older Adults With Obesity

Authors

Giulia Gregori
Arjun Paudyal
Yoann Barnouin
Alessandra Celli
Martha Belen Segoviano-Escobar
Reina Armamento-Villareal
Nicola Napoli
Clifford Qualls
Dennis T Villareal

Publication Date

1-1-2023

Journal

Frontiers in Endocrinology

DOI

10.3389/fendo.2023.1279321

PMID

38027147

PMCID

PMC10660264

PubMedCentral® Posted Date

11-7-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Aged, Sarcopenia, Bone Density, Finite Element Analysis, Hand Strength, Obesity, Fractures, Bone, adiposity, aging, sarcopenia, bone quality, body composition, muscle strength

Abstract

BACKGROUND: The expanding population of older adults with obesity is a public health challenge, in part, because of the increased risk of fractures despite normal or high bone mineral density. Potential factors predisposing to fractures in this group include sarcopenia associated with obesity and impaired bone quality. We aimed to determine the contribution of sarcopenic obesity (SO) indices to bone strength as assessed by microfinite element analysis (μFEA) of high-resolution peripheral quantitative computed tomography (HR-pQCT).

METHODS: One-hundred eighty-nine older (age ≥ 65 years) adults with obesity (BMI ≥ 30 kg/m

RESULTS: Both ALM/W and HGS were positively correlated explaining 28% to 36% of the variance in failure load and stiffness at the distal radius and tibia (all

CONCLUSION: These findings demonstrate that lower muscle mass and strength and higher fat mass may impair bone quality. Therefore, interventions that focus on preserving muscle mass and strength while reducing fat mass may be important to decrease fracture risk when older adults with obesity undertake lifestyle intervention therapy.

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