Steroid Receptor Coactivators in Treg and Th17 Cell Biology and Function

Authors

Yosi Gilad
Ortal Shimon
Sang Jun Han
David M Lonard
Bert W O'Malley

Publication Date

1-1-2024

Journal

Frontiers in Immunology

DOI

10.3389/fimmu.2024.1389041

PMID

38698860

PMCID

PMC11063348

PubMedCentral® Posted Date

4-18-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Neoplasms, Nuclear Receptor Coactivators, T-Lymphocytes, Regulatory, Th17 Cells, steroid receptor coactivators (SRCs), nuclear coactivators (NCoAs), Th17 cells, Treg cells, cell therapy

Abstract

Steroid receptor coactivators (SRCs) are master regulators of transcription that play key roles in human physiology and pathology. SRCs are particularly important for the regulation of the immune system with major roles in lymphocyte fate determination and function, macrophage activity, regulation of nuclear factor κB (NF-κB) transcriptional activity and other immune system biology. The three members of the p160 SRC family comprise a network of immune-regulatory proteins that can function independently or act in synergy with each other, and compensate for - or moderate - the activity of other SRCs. Recent evidence indicates that the SRCs are key participants in governing numerous aspects of CD4+ T cell biology. Here we review findings that establish the SRCs as essential regulators of regulatory T cells (Tregs) and T helper 17 (Th17) cells, with a focus on their crucial roles in Treg immunity in cancer and Treg-Th17 cell phenotypic plasticity.