A Comprehensive Analysis of Lung Cancer Highlighting Epidemiological Factors and Psychiatric Comorbidities from the All of Us Research Program

Authors

Vikram R Shaw
Jinyoung Byun
Rowland W Pettit
Younghun Han
David A Hsiou
Luke A Nordstrom
Christopher I Amos

Publication Date

7-5-2023

Journal

Scientific Reports

DOI

10.1038/s41598-023-37585-0

PMID

37407606

PMCID

PMC10322929

PubMedCentral® Posted Date

7-5-2023

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

Humans, United States, Case-Control Studies, Cr/oss-Sectional Studies, Population Health, Comorbidity, Lung Neoplasms, Risk Factors, Cancer epidemiology, Lung cancer, Risk factors

Abstract

Lung cancer is the leading cause of cancer-related mortality in the United States. Investigating epidemiological and clinical parameters can contribute to an improved understanding of disease development and management. In this cross-sectional, case-control study, we used the All of Us database to compare healthcare access, family history, smoking-related behaviors, and psychiatric comorbidities in light smoking controls, matched smoking controls, and primary and secondary lung cancer patients. We found a decreased odds of primary lung cancer patients versus matched smoking controls reporting inability to afford follow-up or specialist care. Additionally, we found a significantly increased odds of secondary lung cancer patients having comorbid anxiety and insomnia when compared to matched smoking controls. Our study provides a profile of the psychiatric disease burden in lung cancer patients and reports key epidemiological factors in patients with primary and secondary lung cancer. By using two controls, we were able to separate smoking behavior from lung cancer and identify factors that were mediated by heavy smoking alone or by both smoking and lung cancer.

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