Tissue-Resident Memory T Cell Signatures from Single-Cell Analysis Associated with Better Melanoma Prognosis

Authors

Chongming Jiang
Cheng-Chi Chao
Jianrong Li
Xin Ge
Aidan Shen
Vadim Jucaud
Chao Cheng
Xiling Shen

Publication Date

3-15-2024

Journal

iScience

DOI

10.1016/j.isci.2024.109277

PMID

38455971

PMCID

PMC10918229

PubMedCentral® Posted Date

2-20-2024

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

Microenvironment, Immunology, Cancer

Abstract

Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated. Here, we systematically investigated the relationship between TRM and melanoma TIME based on multiple clinical single-cell RNA-seq datasets and developed signatures indicative of TRM infiltration. TRM infiltration is associated with longer overall survival and abundance of T cells, NK cells, M1 macrophages, and memory B cells in the TIME. A 22-gene TRM–derived risk score was further developed to effectively classify patients into low- and high-risk categories, distinguishing overall survival and immune activation, particularly in T cell-mediated responses. Altogether, our analysis suggests that TRM abundance is associated with melanoma TIME activation and patient survival, and the TRM-based machine learning model can potentially predict prognosis in melanoma patients.

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