Genetic Variants in CYP2B6 and HSD17B12 Associated with Risk of Squamous Cell Carcinoma of the Head and Neck

Authors

Hongliang Liu
Guojun Li
Erich M Sturgis
Sanjay Shete
Kristina R Dahlstrom
Mulong Du
Christopher I Amos
David C Christiani
Philip Lazarus
Qingyi Wei

Publication Date

8-15-2022

Journal

International Journal of Cancer

DOI

10.1002/ijc.34023

PMID

35404482

PMCID

PMC9203942

PubMedCentral® Posted Date

8-15-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

17-Hydroxysteroid Dehydrogenases, Carcinoma, Squamous Cell, Case-Control Studies, Cytochrome P-450 CYP2B6, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Head and Neck Neoplasms, Humans, Oropharyngeal Neoplasms, Polymorphism, Single Nucleotide, RNA, Messenger, Risk Factors, Squamous Cell Carcinoma of Head and Neck, PAH metabolism, tobacco-specific nitrosamines, SNP, squamous cell carcinoma of the head and neck, GWAS, molecular epidemiology

Abstract

Polycyclic aromatic hydrocarbons (PAH) and tobacco-specific nitrosamines (TSNA) metabolism-related genes play an important role in the development of cancers. We assessed the associations of genetic variants in genes involved in the metabolism of PAHs and TSNA with risk of squamous cell carcinoma of the head and neck (SCCHN) in European populations using two published genome-wide association study datasets. In the single-locus analysis, we identified two SNPs (rs145533669 and rs35246205) in CYP2B6 to be associated with risk of SCCHN (P = 1.57 × 10

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