Publication Date
11-1-2020
Journal
Cancer Epidemiology, Biomarkers & Prevention
DOI
10.1158/1055-9965.EPI-20-0026
PMID
32855268
PMCID
PMC8597394
PubMedCentral® Posted Date
11-17-2021
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Smoking, Surveys and Questionnaires, Young Adult, American Indian or Alaska Native
Abstract
BACKGROUND: The smoking behavior of American Indians (AI) differs from that of non-Hispanic whites (NHW). Typically light smokers, cessation interventions in AIs are generally less effective. To develop more effective cessation programs for AIs, clinicians, researchers, and public health workers need a better understanding of the genetic factors involved in their smoking behavior. Our aim was to assess whether SNPs associated with smoking behavior in NHWs are also associated with smoking in AIs.
METHODS: We collected questionnaire data on smoking behaviors and analyzed blood and saliva samples from two Tribal populations with dramatically different cultures and smoking prevalence, one in the Northern Plains (
RESULTS: Among 499 participants, we identified, in the Northern Plains sample only, a variant of the gamma-aminobutyric acid receptor subunit alpha-2 (
CONCLUSIONS: The contribution of many genes known to underlie smoking behaviors in NHWs may differ in AIs.
IMPACT: Once validated, these variants could be useful in developing more effective cessation strategies.
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