Publication Date
10-12-2024
Journal
Scientific Reports
DOI
10.1038/s41598-024-75305-4
PMID
39396092
PMCID
PMC11470916
PubMedCentral® Posted Date
10-12-2024
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Humans, Colorectal Neoplasms, Female, Mendelian Randomization Analysis, Lung Neoplasms, Genome-Wide Association Study, Gonadal Steroid Hormones, Sex Hormone-Binding Globulin, Risk Factors, Testosterone, Polymorphism, Single Nucleotide, Middle Aged, White People, Cancer epidemiology, Lung cancer, Colorectal cancer, Endocrinology, Epidemiology, Genetics research, Colorectal cancer, Estradiol, HUNT, Lung cancer, Sex hormones
Abstract
The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37-0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.
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Diseases Commons, Epidemiology Commons, Medical Genetics Commons, Medical Immunology Commons, Oncology Commons
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