Clustering of Pediatric Brain Tumors in Texas, 2000-2017

Authors

Thanh T Hoang
Omar Rosales
Elyse Burgess
Philip J Lupo
Michael E Scheurer
Abiodun O Oluyomi

Publication Date

4-8-2023

Journal

Toxics

DOI

10.3390/toxics11040351

PMID

37112578

PMCID

PMC10146099

PubMedCentral® Posted Date

4-8-2023

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

childhood brain tumors, hot spot analysis, cluster analysis, central nervous system tumors

Abstract

Risk factors for pediatric brain tumors are largely unknown. Identifying spatial clusters of these rare tumors on the basis of residential address may provide insights into childhood socio-environmental factors that increase susceptibility. From 2000-2017, the Texas Cancer Registry recorded 4305 primary brain tumors diagnosed among children (≤19 years old). We performed a spatial analysis in SaTScan to identify neighborhoods (census tracts) where the observed number of pediatric brain tumors was higher than expected. Within each census tract, the number of pediatric brain tumors was summed on the basis of residential address at diagnosis. The population estimate from the 2007-2011 American Community Survey of 0- to 19-year-olds was used as the at-risk population.

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