Publication Date
8-13-2020
Journal
Oncogenesis
DOI
10.1038/s41389-020-00257-z
PMID
32792499
PMCID
PMC7426958
PubMedCentral® Posted Date
8-13-2020
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Cancer, Cell biology
Abstract
Antibodies against programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the landscape of therapies for non-small cell lung carcinoma (NSCLC); however, the majority of patients do not respond to these agents. In addition, hyperprogressive disease (HPD) develops in a larger portion of NSCLC patients treated with PD-1/PD-L1 inhibitors than in patients treated with standard chemotherapy. The use of chimeric antigen receptor (CAR) T cells has been successful to treat blood cancers but not for solid tumors like NSCLC. In this work, we constructed CAR T cells that target PD-L1 and evaluated their efficacy in NSCLC with either high or low PD-L1 expression. PD-L1-CAR T cells exhibited antigen-specific activation, cytokine production, and cytotoxic activity against PD-L1
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