Language
English
Publication Date
1-1-2023
Journal
Digestive and Liver Disease
DOI
10.1016/j.dld.2022.09.006
PMID
36182570
PMCID
PMC9534558
PubMedCentral® Posted Date
9-29-2022
PubMedCentral® Full Text Version
Post-Print
Abstract
BACKGROUND: Global pandemic of COVID-19 represents an unprecedented challenge. COVID-19 has predominantly targeted vulnerable populations with pre-existing chronic medical diseases, such as diabetes and chronic liver disease.
AIMS: We estimated chronic liver disease-related mortality trends among individuals with diabetes before and during the COVID-19 pandemic.
METHODS: Utilizing the US national mortality database and Census, we determined the quarterly age-standardized chronic liver disease-related mortality and quarterly percentage change (QPC) among individuals with diabetes.
RESULTS: The quarterly age-standardized mortality for chronic liver disease and/or cirrhosis among individuals with diabetes remained stable before the COVID-19 pandemic and sharply increased during the COIVD-19 pandemic at a QPC of 8.5%. The quarterly mortality from nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) increased markedly during the COVID-19 pandemic. Mortality for hepatitis C virus (HCV) infection declined with a quarterly rate of -3.3% before the COVID-19 pandemic and remained stable during the COVID-19 pandemic. While ALD- and HCV-related mortality was higher in men than in women, NAFLD-related mortality in women was higher than in men.
CONCLUSIONS: The sharp increase in mortality for chronic liver disease and/or cirrhosis among individuals with diabetes during the COVID-19 pandemic was associated with increased mortality from NAFLD and ALD.
Keywords
Male, Humans, Female, United States, Non-alcoholic Fatty Liver Disease, Pandemics, COVID-19, Liver Cirrhosis, Hepatitis C, Hepacivirus, Diabetes Mellitus, Nonalcoholic fatty liver disease, Alcohol-related liver disease, Cirrhosis, Hepatitis
Published Open-Access
yes
Recommended Citation
Kim, Donghee; Alshuwaykh, Omar; Dennis, Brittany B; et al., "Chronic Liver Disease-Related Mortality in Diabetes Before and During the COVID-19 in the United States" (2023). Faculty and Staff Publications. 1348.
https://digitalcommons.library.tmc.edu/baylor_docs/1348
Included in
COVID-19 Commons, Digestive System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Epidemiology Commons, Gastroenterology Commons, Hepatology Commons, Medical Sciences Commons