Language
English
Publication Date
1-1-2022
Journal
Frontiers in Immunology
DOI
10.3389/fimmu.2022.1049908
PMID
36726990
PMCID
PMC9885262
PubMedCentral® Posted Date
1-13-2023
PubMedCentral® Full Text Version
Post-Print
Abstract
BACKGROUND AND AIM: We previously reported that vonoprazan-amoxicillin (VA) dual therapy for 7 or 10 days is not satisfactorily efficacious for
METHODS: This was a single center, prospective, open-labeled, randomized non-inferiority clinical study conducted in China. Treatment naïve
RESULTS: A total of 154 patients were assessed and 110 subjects were randomized. The eradication rate of VPZ with b.i.d. amoxicillin or t.i.d. amoxicillin for 14 days was 89.1% and 87.3% by intention-to-treat analysis, respectively, and 94.1% and 95.9% by per-protocol analysis, respectively. The eradication rate and incidence of adverse events were not different between the two groups.
CONCLUSION: VPZ with b.i.d. or t.i.d. amoxicillin for 14 days provides satisfactory efficacy as a first-line treatment for
Keywords
Humans, Amoxicillin, Anti-Bacterial Agents, Clarithromycin, Helicobacter Infections, Helicobacter pylori, Prospective Studies, Proton Pump Inhibitors
Published Open-Access
yes
Recommended Citation
Hu, Yi; Xu, Xin; Liu, Xiao-Shun; et al., "Fourteen-Day Vonoprazan and Low- or High-Dose Amoxicillin Dual Therapy for Eradicating Helicobacter pylori Infection: A Prospective, Open-Labeled, Randomized Non-inferiority Clinical Study" (2022). Faculty and Staff Publications. 1382.
https://digitalcommons.library.tmc.edu/baylor_docs/1382