Publication Date
7-1-2021
Journal
Clocks Sleep
DOI
10.3390/clockssleep3030025
PMID
34287254
PMCID
PMC8293063
PubMedCentral® Posted Date
7-1-2021
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
sleep, gut microbiome, circadian rhythm, diet, Sutterella
Abstract
We examined the association between the colonic adherent microbiota and nocturnal sleep duration in humans. In a cross-sectional study, 63 polyp-free adults underwent a colonoscopy and donated 206 mucosal biopsies. The gut microbiota was profiled using the 16S rRNA gene sequencing targeting the V4 region. The sequence reads were processed using UPARSE and DADA2, respectively. Lifestyle factors, including sleep habits, were obtained using an interviewer-administered questionnaire. We categorized the participants into short sleepers (<6 h per night; n = 16) and normal sleepers (6–8 h per night; n = 47) based on self-reported data. Differences in bacterial biodiversity and the taxonomic relative abundance were compared between short vs. normal sleepers, followed by multivariable analysis. A false discovery rate-adjusted p value (q value) < 0.05 indicated statistical significance. The bacterial community composition differed in short and normal sleepers. The relative abundance of Sutterella was significantly lower (0.38% vs. 1.25%) and that of Pseudomonas was significantly higher (0.14% vs. 0.08%) in short sleepers than in normal sleepers (q values < 0.01). The difference was confirmed in the multivariable analysis. Nocturnal sleep duration was associated with the bacterial community composition and structure in the colonic gut microbiota in adults.
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Digestive System Diseases Commons, Gastroenterology Commons, Medical Immunology Commons, Medical Microbiology Commons
Comments
Associated Data