Concurrent HBsAg and Anti-HBs Induced by a PreS Deletion Mutant in a Chronic Hepatitis B Patient

Authors

Wen Wu
Yingjian Chen
F Blaine Hollinger
Xiangyan Huang

Language

English

Publication Date

1-1-2024

Journal

American Journal of Translational Research

DOI

10.62347/XLXN1569

PMID

39262753

PMCID

PMC11384356

PubMedCentral® Posted Date

8-15-2024

PubMedCentral® Full Text Version

Post-Print

Abstract

This study analyzed the origins of concurrent hepatitis B surface antigen (HBsAg) and HBsAg antibodies (anti-HBs) in a patient with chronic hepatitis B virus (HBV) infection. The levels of serological markers of HBV infection were determined by enzyme-linked immunosorbent assay (ELISA). The preS/S gene was analyzed by gene amplification and sequencing. The tests revealed that HBsAg and anti-HBs coexisted in this patient with mixed infections of the full-length preS/S virus strain and preS1 183 bp deletion mutant, and both the mutant and the anti-HBs were no longer present after one year, which means that the mutant strain was cleared by the detected antibodies. Thus, it is speculated that anti-HBs antibodies targeted specifically to the preS1 deletion mutant strain instead of the strain with the full-length large S protein were produced. This mechanism is quite different from other immunopathogenic mechanisms for concurrent HBsAg and anti-HBs.

Keywords

Hepatitis B virus, chronic hepatitis B, HBsAg, anti-HBs, preS deletion mutant

Published Open-Access

yes

Recommended Citation

Wu, Wen; Chen, Yingjian; Hollinger, F Blaine; et al., "Concurrent HBsAg and Anti-HBs Induced by a PreS Deletion Mutant in a Chronic Hepatitis B Patient" (2024). Faculty and Staff Publications. 1416.
https://digitalcommons.library.tmc.edu/baylor_docs/1416