Publication Date
1-1-2024
Journal
American Journal of Translational Research
DOI
10.62347/XLXN1569
PMID
39262753
PMCID
PMC11384356
PubMedCentral® Posted Date
8-15-2024
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Hepatitis B virus, chronic hepatitis B, HBsAg, anti-HBs, preS deletion mutant
Abstract
This study analyzed the origins of concurrent hepatitis B surface antigen (HBsAg) and HBsAg antibodies (anti-HBs) in a patient with chronic hepatitis B virus (HBV) infection. The levels of serological markers of HBV infection were determined by enzyme-linked immunosorbent assay (ELISA). The preS/S gene was analyzed by gene amplification and sequencing. The tests revealed that HBsAg and anti-HBs coexisted in this patient with mixed infections of the full-length preS/S virus strain and preS1 183 bp deletion mutant, and both the mutant and the anti-HBs were no longer present after one year, which means that the mutant strain was cleared by the detected antibodies. Thus, it is speculated that anti-HBs antibodies targeted specifically to the preS1 deletion mutant strain instead of the strain with the full-length large S protein were produced. This mechanism is quite different from other immunopathogenic mechanisms for concurrent HBsAg and anti-HBs.
Included in
Digestive System Diseases Commons, Gastroenterology Commons, Hepatology Commons, Medical Sciences Commons