The Prevalence, Etiology and Treatment of Gastroduodenal Ulcers and Perforation: A Systematic Review

Authors

Rizki Amalia
Amie Vidyani
Reny I'tishom
Wiwin Is Efendi
Edwin Danardono
Bogi Pratomo Wibowo
Muhammad Lutfi Parewangi
Muhammad Miftahussurur
Hoda M Malaty

Publication Date

2-13-2024

Journal

Journal of Clinical Medicine

DOI

10.3390/jcm13041063

PMID

38398375

PMCID

PMC10888557

PubMedCentral® Posted Date

2-13-2024

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

gastroduodenal, perforation, Helicobacter pylori infection, NSAIDs, humans and disease

Abstract

(1) Background: Gastroduodenal perforation (GDP) is a life-threatening condition caused by a spontaneous or traumatic event. Treatment should be based on the mechanism of damage, timing, location, extent of the injury, and the patient's clinical condition. We aimed to examine several etiologic factors associated with gastroduodenal perforation and to search for the best method(s) for its prevention and treatment. (2) Methods: We conducted extensive literature reviews by searching numerous studies obtained from PubMed, Science Direct, and Cochrane for the following keywords: gastroduodenal perforation,

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