Language
English
Publication Date
1-1-2021
Journal
PLoS One
DOI
10.1371/journal.pone.0260019
PMID
34780551
PMCID
PMC8592489
PubMedCentral® Posted Date
11-15-2021
PubMedCentral® Full Text Version
Post-Print
Abstract
BACKGROUND: Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various parameters of alcohol use and risk of gastric intestinal metaplasia.
METHODS: We used data from 2084 participants (including 403 with gastric intestinal metaplasia) recruited between February 2008-August 2013 into a cross-sectional study at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas. All participants underwent a study upper endoscopy with systematic gastric mapping biopsies. Cases had intestinal metaplasia on any non-cardia gastric biopsy. Participants self-reported lifetime history of alcohol consumption, along with other lifestyle risk factors, through a study survey. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for categories of average alcohol consumption using multivariable logistic regression, and restricted cubic spline regression to explore the potential shape of a dose-response relationship.
RESULTS: Compared to lifelong non-drinkers, individuals who consumed on average ≥28 drinks per week had no elevated risk for gastric intestinal metaplasia (adjusted OR, 1.27; 95% CI, 0.74-2.19). Based on a spline regression curve and its 95% CI, there was also no demonstrable association between cumulative lifetime alcohol consumption and risk of gastric intestinal metaplasia. Similarly, we found no association between beverage type (beer, wine, liquor/spirits) and risk for gastric intestinal metaplasia.
CONCLUSIONS: Neither amount of alcohol consumed nor specific beverage type was associated with risk of gastric intestinal metaplasia.
Keywords
Aged, Alcohol Drinking, Biopsy, Cross-Sectional Studies, Female, Humans, Intestines, Logistic Models, Male, Metaplasia, Middle Aged, United States, Veterans
Published Open-Access
yes
Recommended Citation
Holmes, Hudson M; Jove, Andre G; Tan, Mimi C; et al., "Alcohol Consumption and the Risk of Gastric Intestinal Metaplasia in a US Veterans Population" (2021). Faculty and Staff Publications. 1472.
https://digitalcommons.library.tmc.edu/baylor_docs/1472