Language

English

Publication Date

8-1-2024

Journal

Cognitive Therapy and Research

DOI

10.1007/s10608-024-10474-0

PMID

39664885

PMCID

PMC11634056

PubMedCentral® Posted Date

12-11-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

PURPOSE: This is a secondary analysis of a multi-site, cluster (site) randomized trial of the efficacy of a combined Health and Wellness Cognitive Behavior Therapy (H&W CBT) and medication management approach for depression in youth with HIV (YWH) compared to standard care. In this study, we explored the association between H&W CBT factors and depression outcomes after 24 weeks of treatment to discover treatment elements associated with symptom reduction.

METHODS: Participants (12-24 years of age) were YWH in the United States (US) diagnosed with moderate to severe depression [Quick Inventory of Depressive Symptomatology (QIDS), Clinician-Rated score ≥ 11]. Thirteen US sites were randomly assigned to either the combination treatment approach or standard care. For site-level analyses, site-specific summary scores were used to account for the within site correlation.

RESULTS ALL SCORES ARE SITE-LEVEL: The number of depressive symptoms [QIDS-Self Reported (QIDS-SR) score] after 24 weeks of H&W CBT was significantly negatively correlated with the mean total session duration (ρ = - 0.94), the total homework assigned (ρ = - 0.83), the total number of practice modules used (ρ = - 0.83), and the mean total booster sessions given (ρ = - 0.82).

CONCLUSIONS: Specific elements of the H&W CBT (e.g., dose, assignment of homework, greater skills practice, and use of booster sessions) were associated with improvement of depression outcomes in YWH. A focus on these elements in treatment may improve symptom reduction for YWH with depression.

Keywords

Depression, HIV, Cognitive therapy, Treatment factors

Published Open-Access

yes

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