Vulvar Lichen Sclerosus in Women of Reproductive Age

Authors

Elysha Kolitz
Laura Gammon
Melissa Mauskar

Publication Date

2-22-2021

Journal

Baylor University Medical Center Proceedings

DOI

10.1080/08998280.2021.1885093

PMID

33953458

PMCID

PMC8059896

PubMedCentral® Posted Date

2-21-2021

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

Genital, lichen sclerosus, pregnancy, reproductive age, vulvar lichen sclerosuslichen sclerosus

Abstract

Vulvar lichen sclerosus (vLS) is an inflammatory skin condition that predominantly affects the vulvar and perianal regions. Approximately 50% of cases present prior to menopause; however, there is a paucity of data on vLS in women of reproductive age as well as during their pregnancies. A retrospective review was performed at two tertiary referral centers to better describe cases of vLS in women of reproductive age. Thirty-three patients with a mean age of 40 years met inclusion criteria. In this group, vulvar pruritus was the most common presenting symptom (52%); 61% had biopsy-proven vLS, 42% had at least one autoimmune condition, 21% had comorbid depression or anxiety, 33% were given an incorrect diagnosis prior to vLS, and 42% had documented nonadherence to topical steroids. Among the eight patients who became pregnant, four had cesarean deliveries and 63% were symptomatic during pregnancy. When treating a woman who presents with vulvar pruritus or skin changes, vLS should be considered.