Language

English

Publication Date

12-12-2022

Journal

Cancer Cell

DOI

10.1016/j.ccell.2022.09.017

PMID

36270276

PMCID

PMC10576652

PubMedCentral® Posted Date

10-14-2023

PubMedCentral® Full Text Version

Author MSS

Abstract

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.

Keywords

Humans, Neoplasms, Precision Medicine, Prospective Studies, Medical Oncology

Published Open-Access

yes

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