An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma

Authors

Sarah Premji
Andreia Barbieri
Christine Roth
Eric M Rohren
Gustavo Rivero
Sravanti P Teegavarapu

Publication Date

1-1-2022

Journal

Case Reports in Hematology

DOI

10.1155/2022/4700787

PMID

35721802

PMCID

PMC9203203

PubMedCentral® Posted Date

6-9-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Abstract

INTRODUCTION: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare disease entity associated with textured breast implants. Though the clinical course is typically indolent, BIA-ALCL can occasionally invade through the capsule into the breast parenchyma with spread to the regional lymph nodes and beyond including chest wall invasive disease.

CASE: We present the case of a 51-year-old female with a history of bilateral silicone breast implants placed approximately twenty years ago who presented with two months of progressively enlarging right breast mass. Ultrasound-guided biopsy of right breast mass and right axillary lymph node showed CD 30-positive

CONCLUSION: Treatment guidelines for advanced chest wall invasive BIA-ALCL are not well defined. Lack of predictive factors warrants mutation analysis and genetic sequencing to identify those at highest risk of progression to chest wall invasive disease. This rare case highlights the need for definitive consensus on the optimal management of chest wall invasive BIA-ALCL.

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