Language
English
Publication Date
7-26-2021
Journal
BMJ Case Reports
DOI
10.1136/bcr-2021-243173
PMID
34312136
PMCID
PMC8314742
PubMedCentral® Posted Date
7-24-2021
PubMedCentral® Full Text Version
Post-print
Abstract
A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.
Keywords
2019-nCoV Vaccine mRNA-1273, COVID-19 Vaccines, Encephalitis, Humans, Myoclonus, Sweet Syndrome
Published Open-Access
yes
Recommended Citation
Torrealba-Acosta, Gabriel; Martin, Jennifer C; Huttenbach, Yve; et al., "Acute Encephalitis, Myoclonus and Sweet Syndrome After mRNA-1273 Vaccine" (2021). Faculty and Staff Publications. 1624.
https://digitalcommons.library.tmc.edu/baylor_docs/1624
Included in
Allergy and Immunology Commons, Immune System Diseases Commons, Medical Immunology Commons