Language
English
Publication Date
1-3-2024
Journal
Nature Communications
DOI
10.1038/s41467-023-44090-5
PMID
38172101
PMCID
PMC10764789
PubMedCentral® Posted Date
1-3-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
Keywords
Female, Humans, SARS-CoV-2, COVID-19, B-Lymphocytes, Body Fluids, Disease Progression, Phenotype
Published Open-Access
yes
Recommended Citation
Ozonoff, Al; Jayavelu, Naresh Doni; Liu, Shanshan; et al., "Features of Acute COVID-19 Associated With Post-acute Sequelae of SARS-CoV-2 Phenotypes: Results From the IMPACC Study" (2024). Faculty and Staff Publications. 1625.
https://digitalcommons.library.tmc.edu/baylor_docs/1625
Included in
Allergy and Immunology Commons, Clinical Epidemiology Commons, COVID-19 Commons, Immune System Diseases Commons, Medical Immunology Commons