Publication Date
2-1-2025
Journal
Journal of Immunotherapy and Precision Oncology
DOI
10.36401/JIPO-24-7
PMID
39811426
PMCID
PMC11728380
PubMedCentral® Posted Date
1-10-2025
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
: immunoglobulins, cancer, transplant, autoimmune disorders, neurological disorders
Abstract
Immunoglobulins (Igs) are produced by B lymphocytes and play a key role in humoral immunity. Igs are classified into five isotypes (IgG, IgA, IgM, IgE, and IgD). Their primary function is to recognize and bind to foreign antigens. When Igs bind to antigens, they facilitate phagocytosis and promote clearance mediated by other immune cells. It is an essential component in protecting the host from outside pathogens. Hypogammaglobulinemia predisposes an individual to severe and recurrent infections. Therefore, replacement therapy is recommended to maintain optimal Ig level. In addition, Igs can modulate immune responses by to neutralizing proteins such as endotoxins or receptor-binding antibodies. They can be used to manage excessive immune reactions and autoimmune-related diseases. In this review, we aimed to summarize the clinical indications for Ig therapy for practicing oncologists.
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Allergy and Immunology Commons, Immune System Diseases Commons, Medical Immunology Commons
