Loss of Stearoyl-CoA Desaturase 2 Disrupts Inflammatory Response in Macrophages

Authors

Joseph B Lin
Amy Mora
Tzu Jui Wang
Andrea Santeford
Darksha Usmani
Marianne M Ligon
Indira U Mysorekar
Rajendra S Apte

Publication Date

8-31-2023

Journal

mBio

DOI

10.1128/mbio.00925-23

PMID

37417745

PMCID

PMC10470784

PubMedCentral® Posted Date

7-7-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Animals, Mice, Base Sequence, Fatty Acids, Inflammation, Lipopolysaccharides, Macrophages, Stearoyl-CoA Desaturase, macrophage, UPEC, IL1B, inflammaging, cardiolipin, stearoyl-CoA desaturase

Abstract

Macrophages are innate immune cells that patrol tissues and are the first responders to detect infection. They orchestrate the host immune response in eliminating invading pathogens and the subsequent transition from inflammation to tissue repair. Macrophage dysfunction contributes to age-related pathologies, including low-grade inflammation in advanced age that is termed "inflammaging." Our laboratory has previously identified that macrophage expression of a fatty acid desaturase, stearoyl-CoA desaturase 2 (SCD2), declines with age. Herein, we delineate the precise cellular effects of SCD2 deficiency in murine macrophages. We found that deletion of

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