Publication Date
5-28-2024
Journal
Diagnostics
DOI
10.3390/diagnostics14111119
PMID
38893645
PMCID
PMC11171670
PubMedCentral® Posted Date
5-28-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
vascular inflammation, endothelial dysfunction
Abstract
Hyperglycemia and pulmonary hypertension (PH) share common pathological pathways that lead to vascular dysfunction and resultant cardiovascular complications. These shared pathologic pathways involve endothelial dysfunction, inflammation, oxidative stress, and hormonal imbalances. Individuals with hyperglycemia or pulmonary hypertension also possess shared clinical factors that contribute to increased morbidity from both diseases. This review aims to explore the relationship between PH and hyperglycemia, highlighting the mechanisms underlying their association and discussing the clinical implications. Understanding these common pathologic and clinical factors will enable early detection for those at-risk for complications from both diseases, paving the way for improved research and targeted therapeutics.
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Critical Care Commons, Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Internal Medicine Commons, Medical Sciences Commons, Pulmonology Commons, Respiratory Tract Diseases Commons, Sleep Medicine Commons