Publication Date
1-1-2024
Journal
Frontiers in Transplantation
DOI
10.3389/frtra.2024.1280280
PMID
38993781
PMCID
PMC11235366
PubMedCentral® Posted Date
4-9-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
CMV, solid organ transplant, kidney transplantation, immunosuppression, prophylaxis
Abstract
Cytomegalovirus (CMV) infection poses a significant threat to solid organ transplant (SOT) recipients and can lead to various complications and adverse outcomes. In an effort to prevent CMV infection, it is common to utilize prophylactic strategies, including antiviral medications such as valganciclovir, especially for high-risk patients. Risk factors for CMV infection in kidney transplant recipients (KTRs) include CMV mismatch between donor and recipient (i.e., donor positive, recipient negative), and intensity of immunosuppression, such as the use of T-cell depleting agents. However, little attention has been given to KTRs with a history of prior SOTs, despite their prolonged exposure to immunosuppressive regimens. The aim of this retrospective single-center study was to investigate the incidence and implications of CMV DNAemia in KTRs with prior SOTs. The study included 97 KTRs with prior SOTs and 154 KTRs with no prior transplants as a control group. In the study group, the most common SOT before the current kidney transplantation (KT), was a previous KT. Patients in the KTR group with prior SOTs were more sensitized than those in the control group [calculated panel-reactive antibody > 30%: 49 (50.5%) vs. 30 (19.45%) patients,
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Immunopathology Commons, Medical Immunology Commons, Nephrology Commons, Other Immunology and Infectious Disease Commons, Surgery Commons
Comments
Associated Data